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A Generalized Quantile Tree Method for Subgroup Identification
One primary goal of subgroup analysis is to identify subgroups of subjects with differential treatment effects. Existing methods have focused on the mean treatment effect and may be ineffective when the two distributions differ in scales or in the upper or lower tails. We develop a new generalized quantile tree method for subgroup identification. The method first uses quantile rank score tests to select split variables and then estimates the split point by minimizing a composite quantile loss. The proposed split rule is free of variable selection bias and robust against outliers and heavy-tailed distributions. In addition, we introduce a generalized quantile treatment effect estimator and a testing method for the selection and confirmation of predictive subgroups. Simulation shows that the proposed method gives more accurate subgroup identification than existing methods for cases with heteroscedastic or heavy-tailed errors. The practical value of the method is demonstrated through the analysis of an AIDS clinical trial data. Supplementary materials for this article are available online.
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