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Nanomaterial-Enhanced Fiber Optofluidic Laser Biosensor for Sensitive Enzyme Detection

A novel fiber optofluidic laser biosensor based on nanoparticle-functionalized thin-walled hollow optical fiber is developed for sensitive detection of enzyme horseradish peroxidase (HRP). High sensitivity is achieved thanks to the high surface-to-volume ratio of the nanomaterials. Two kinds of attractive nanomaterials, i.e., Au nanorods and SiO2 nanoparticles, are selected as demonstrative models to be coated onto the inner surface of thin-walled hollow fiber through electrostatic adsorption and biochemical cross-linking, respectively, while the streptavidin-biotin conjugation mechanism acts as a bridge for the specific recognition of enzyme. The nanoparticle-functionalized fiber optofluidic lasers have lower lasing threshold, compared to the control group without nanomaterial. We experimentally demonstrate that the nanomaterials enhanced fiber optofluidic laser biosensors can detect HRP in the range of 75-15 000 pM with a good linearity in semi-logarithmic scale, and with a sensitivity enhancement of 57.4% by using the SiO2 nanoparticles. We believe that this nanoparticle-enhanced fiber optofluidic laser biosensor could provide an efficient strategy for biomolecule detection such as enzyme-linked immunosorbent assay (ELISA).

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Informasi Detail

Judul Seri

JOURNAL OF LIGHTWAVE TECHNOLOGY; Vol.38 No.18 September 15 2020

No. Panggil

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Penerbit

: .,

Deskripsi Fisik

p. 5205 - 5211

Bahasa

English

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

-

Edisi

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Subjek

OPTICAL FIBER SENSOR
BIOSENSOR
NANOMATERIAL
OPTOFLUIDIC LASER

Info Detail Spesifik

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Pernyataan Tanggungjawab

Jiangui Mao, Xi Yang, Yiling Liu, Yanqiong Wang, Gang-Ding Peng, Yun-Jiang Rao, Yuan Gong

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