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Optofluidic Flow-Through Biosensor Sensitivity – Model and Experiment

We present a model and simulation for predicting the detected signal of a fluorescence-based optical biosensor built from optofluidic waveguides. Typical applications include flow experiments to determine pathogen concentrations in a biological sample after tagging relevant DNA or RNA sequences. An overview of the biosensor geometry and fabrication processes is presented. The basis for the predictive model is also outlined. The model is then compared to experimental results for three different biosensor designs. The model is shown to have similar signal statistics as physical tests, illustrating utility as a pre-fabrication design tool and as a predictor of detection sensitivity.

Ketersediaan

Informasi Detail

Judul Seri

JOURNAL OF LIGHTWAVE TECHNOLOGY; Vol.39 No.10 May 15 2021

No. Panggil

-

Penerbit

: .,

Deskripsi Fisik

p. 3330 - 3340

Bahasa

English

ISBN/ISSN

-

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

OPTOFLUIDICS
INTEGRATED WAVEGUIDES
ANTI-RESONANT REFLECTING OPTICAL WAVEGUIDES (ARROW
MODEL DESIGN
PREDICTIVE SIMULATION

Info Detail Spesifik

DOI: 10.1109/JLT.2021.3061872

Pernyataan Tanggungjawab

Joel G. Wright, Md Nafiz Amin, Gopikrishnan G. Meena, Holger Schmidt, Aaron R. Hawkins

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