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Tracking Single Particles Using Surface Plasmon Leakage Radiation Speckle

Label free tracking of small bio-particles such as proteins or viruses is of great utility in the study of biological processes, however such experiments are frequently hindered by weak signal strengths and a susceptibility to scattering impurities. To overcome these problems we here propose a novel technique leveraging the enhanced sensitivity of both interferometric detection and the strong field confinement of surface plasmons. Specifically, we show that interference between the field scattered by an analyte particle and a speckle reference field, derived from random scattering of surface plasmons propagating on a rough metal film, enables particle tracking with sub-wavelength accuracy. We present the analytic framework of our technique and verify its robustness to noise through Monte Carlo simulations.

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Informasi Detail

Judul Seri

JOURNAL OF LIGHTWAVE TECHNOLOGY; Vol.39 No.12 June 15 2021

No. Panggil

-

Penerbit

: .,

Deskripsi Fisik

p. 3950 - 3960

Bahasa

English

ISBN/ISSN

-

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

PLASMONS
INTERFERENCE
SPECKLE
PARTICLE TRACKING
ELECTROMAGNETIC SURFACE WAVES
ELECTROMAGNETIC SCATTERING BY ROUGH SURFACES

Info Detail Spesifik

DOI: 10.1109/JLT.2020.3035820

Pernyataan Tanggungjawab

Joel Berk, Carl Paterson, Matthew R. Foreman

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